Research Article

Comparative Genomics of Three-domain Multi-copper Oxidase Gene Family in Foxtail Millet (Setaria italica L.)  

Huilong Chen , Xiyin Wang , Weina Ge
College of Life Sciences, North China University of Science and Technology, Tangshan, 063000, China
Author    Correspondence author
Computational Molecular Biology, 2021, Vol. 11, No. 4   doi: 10.5376/cmb.2021.11.0004
Received: 10 Aug., 2020    Accepted: 11 Dec., 2020    Published: 21 Mar., 2021
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This article was first published in Molecular Plant Breeding in Chinese, and here was authorized to translate and publish the paper in English under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Chen H.L., Wang X.Y., and Ge W.N., 2021, Comparative genomics of three-domain multi-copper oxidase gene family in foxtail millet (Setaria italica L.), Computational Molecular Biology, 11(4): 1-13 (doi: 10.5376/cmb.2021.11.0004)

Abstract

Three-domain multi-copper oxidase is the largest family in the supergene family of multi-copper oxidase and has multiple biological functions. In this paper, comparative genomics methods were used to analyze the whole genome three-domain multi-copper oxidase gene family in foxtail millet (Setaria italica). The results showed that the three-domain multi-copper oxidase gene family of foxtail millet had undergone a large-scale expansion, mainly caused by the tandem duplication which accured after the formation of foxtail millet species. The three-domain multi-copper oxidase genes of foxtail millet were divided into three groups: I, II, and III. Tandem repeat genes were mainly concentrated in Class I-7 subclass. Selection pressure analysis of this subclass revealed that 7 amino acid sites were positively selected. Foxtail millet three-domain multi-copper oxidase could respond to many abiotic stresses, the expression pattern showed up-regulated under ABA and PEG treatment; under heat stress, most of the gene were down-regulated, and the differentially expressed genes clusted some special subclass; under cold stress and salt stress, there were also many genes with significantly different expressions. This study revealed the evolutionary rules of the three-domain multi-copper oxidase gene family in foxtail millet and provides clues for further study of the gene's function.

Keywords
Foxtail millet; Three-domain multi-copper oxidase; Gene family; Comparative genomics; Abiotic stress
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