Vijya Laxmi , Ranjan Tamuli

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati 781 039, India
Author    Correspondence author
Genomics and Applied Biology, 2015, Vol. 6, No. 7   doi: 10.5376/gab.2015.06.0007
Received: 24 Apr., 2015    Accepted: 02 Aug., 2015    Published: 14 Oct., 2015

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Laxmi V. and Tamuli R., 2015, The Neurospora crassa cmd, trm-9, and nca-2 Play a Role in Growth, Development, and Survival in Stress conditions, Genomics and Applied Biology, Vol.6, No.7, 1-8 (doi: 10.5376/gab.2015.06.0007)

The calmodulin protein antagonists, trifluoperazine (TFP) and chlorpromazine (CPZ) inhibit the growth, carotenoids accumulation and sexual development of Neurospora crassa. In addition, N. crassa strains lacking trm-9, a cation-ATPase, showed defect in growth. Moreover, strains lacking both trm-9 and another Ca²⁺-ATPase nca-2, exhibited a severe growth defect, an increased sensitivity to CaCl₂, and a reduction in acquisition of thermotolerance induced by heat shock temperature. Therefore, the cmd, trm-9, and nca-2 play a role in growth, survival in calcium stress and induced heat shock temperature in N. crassa.

Calcium signaling; Ca²⁺/cation ATPases; Calmodulin; Neurospora crassa; nca-2; thermotolerance