Review and Progress

Assembly and Influencing Factors of IMPDH2 Cytoophidia  

Liwei Shi , Weiwei Zhang
College of Life Sciences, Agriculture and Forestry, Heilongjiang Provincial Key Laboratory of Resistance Gene Engineering and Protection of Biodiversity in Cold Areas, Qiqihar University, Qiqihar, 161006
Author    Correspondence author
Genomics and Applied Biology, 2021, Vol. 12, No. 1   
Received: 10 Aug., 2020    Accepted: 09 Oct., 2020    Published: 18 Mar., 2021
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This article was first published in 《基因组学与应用生物学》(ISSN1674-568X,CN45-1369/Q) in Chinese, and here was authorized to translate and publish the paper in English under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

Cytoophidium is a "rod" or "ring" structure composed of metabolically related enzymes. Inosine-5'-monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme that catalyzes the de novo biosynthetic pathway of guanine nucleotides and plays a very important role in cell proliferation, cell differentiation, maintenance of body balance and metabolism. The study found that IMPDH2 gene can be assembled into a special structure of protein polymer fibers, named IMPDH2 cytoophidia, the structure is a natural biological phenomenon related to purine metabolism, as a fine-tuning protein adapted to the intracellular and extracellular environment changes. This article reviews the structure of IMPDH2 and IMPDH2 cytoophidia, the assembly process and the influencing factors of IMPDH2 cytoophidia.

Keywords
IMPDH2; cytoophidia; Assembly

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