Review and Progress

Advances in Animal Disease Resistance Research: Discoveries of Genetic Markers for Disease Resistance in Cattle through GWAS  

Jue Huang , Xiaofang Lin
Hainan Institute of Tropical Agricultural Resources, Tropical Animal Center, Sanya, 572025, China
Author    Correspondence author
Biological Evidence, 2024, Vol. 14, No. 1   doi: 10.5376/be.2024.14.0004
Received: 05 Jan., 2024    Accepted: 08 Feb., 2024    Published: 20 Feb., 2024
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Preferred citation for this article:

Huang J., and Lin X.F., 2024, Advances in animal disease resistance research: discoveries of genetic markers for disease resistance in cattle through GWAS, Bioscience Evidence, 14(1): 24-31 (doi: 10.5376/be.2024.14.0004)


This study summarizes the recent advancements in the application of GWAS technology in animal disease resistance research, emphasizing the importance and value of such studies. Initially, the genetic basis of animal disease resistance is introduced, with a focus on the relationship between the host immune system and disease resistance, as well as the genetic foundations of disease resistance. Subsequently, the principles, advantages, and historical development of GWAS technology in animal disease resistance research are elucidated. Following this, the application of GWAS technology in the discovery of genetic markers for disease resistance in cattle is discussed, including the research background, design methods, identified genetic markers for disease resistance, and their functional analysis. Finally, the significance of continued attention and support for animal disease resistance research is underscored, advocating for enhanced functional analysis of disease resistance-related genes, improved research data quality and sample sizes to advance animal disease resistance breeding.

GWAS technology; Animal disease resistance; Genetic markers; Cattle; Immune system
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