Rui Wang , Linn Lou

Biotechnology Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, China
Author    Correspondence author
Biological Evidence, 2024, Vol. 14, No. 3   doi: 10.5376/be.2024.14.0013
Received: 09 Apr., 2024    Accepted: 13 May, 2024    Published: 28 May, 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Wang R., and Lou L., 2024, The central role of the citric acid cycle in energy metabolism: from metabolic intermediates to regulatory mechanisms, Bioscience Evidence, 14(3): 110-121 (doi: 10.5376/be.2024.14.0013)

The citric acid cycle (TCA) plays a crucial central role in cellular energy metabolism by linking the breakdown of carbohydrates, fats, and proteins, thereby promoting the generation of ATP and maintaining cellular energy homeostasis. This study systematically explores the metabolic intermediates of the citric acid cycle and its complex regulatory mechanisms, revealing its multifaceted functions in energy metabolism, cellular signaling, and biosynthesis. The results indicate that the citric acid cycle is not only vital for energy production but also directly participates in various biosynthetic pathways within the cell by providing precursors for amino acids, fatty acids, and other essential biomolecules. Additionally, the intermediates of the citric acid cycle play important roles in regulating immune responses, mitophagy, cellular stress responses, and metabolic reprogramming, contributing to cellular stability in response to environmental changes. This study provides new insights into the mechanisms of metabolic disorders and disease development, offering a theoretical basis for the development of novel therapeutic strategies. By gaining an in-depth understanding of the multi-layered regulatory mechanisms of the citric acid cycle, this study will advance scientific studies and practical applications in related fields.

Citric acid cycle; Energy metabolism; Metabolic intermediates; Regulatory mechanisms; Cellular homeostasis; Metabolic engineering