Feature Review
Application and Process Optimization of Supercritical Fluid Technology in the Extraction of Cordyceps Polysaccharides 


Biological Evidence, 2025, Vol. 15, No. 2
Received: 01 Mar., 2025 Accepted: 03 Apr., 2025 Published: 11 Apr., 2025
Cordyceps polysaccharides have become a research focus in the field of functional foods and pharmaceuticals due to their strong biological activity and wide application prospects. Supercritical fluid technology, especially supercritical carbon dioxide (SC-CO2) technology, has the characteristics of high efficiency, environmental protection, and strong selectivity. This study systematically summarized the extraction methods of Cordyceps polysaccharides, with a focus on the application status and process optimization of supercritical fluid technology in Cordyceps polysaccharide extraction. The key factors affecting extraction efficiency were analyzed, and the application of response surface methodology (RSM) in optimizing extraction processes was explored, as well as its role in improving polysaccharide yield and purity. The key technologies for polysaccharide quality control were also summarized. In response to the potential of supercritical fluid technology in the industrialization of Cordyceps polysaccharide extraction, this study proposes directions for green process improvement, multi-objective extraction strategies, and equipment upgrades, providing scientific basis for efficient extraction and quality control of Cordyceps polysaccharides.
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. Wei Wang

. Jia Xuan

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