Zhen Li

Hainan Institute of Biotechnology, Haikou, 570206, Hainan, China
Author    Correspondence author
Biological Evidence, 2025, Vol. 15, No. 5   
Received: 24 Jul., 2025    Accepted: 29 Aug., 2025    Published: 15 Sep., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The development of cotton genomics is closely related to new technologies. High-throughput sequencing enables us to obtain more data, and there are also an increasing number of bioinformatics tools. Some commonly used platforms nowadays include CottonFGD, CottonMD, CottonGen and CottonGVD. These databases collect information at different levels such as the genome, transcriptome, epigenome, metabolome and phenotype. Researchers can use them for gene function annotation, variation detection, trait analysis and molecular breeding. These tools have significantly enhanced research efficiency, helped us better understand complex traits, and promoted precise breeding. In the future, long-read sequencing, pan-genomics, multi-omics integration, and artificial intelligence will all bring new impetus to research. The aim of this study is to summarize the application of these tools and explore their role in precise cotton breeding.

Cotton genomics; Bioinformatics tools; Multi-omics database; Precision breeding; Mining of functional genes