Nesrin Turaclar¹ , Mehmet Koc² , Huseyin Yurdakul³ , Yilmaz Tezcan ² , Hasibe Cingilli Vural⁴

1 Vocational School of Health Services, Selcuk University, Konya, Turkey
2 Department of Radiation Oncology, Meram Medical Faculty of Necmettin Erbakan University, Konya, Turkey
3 Genetikon Lab, Konya,Turkey
4 Department of Medical Biology, Meram Medical Faculty of Necmettin Erbakan University, Konya, Turkey
Author    Correspondence author
Genomics and Applied Biology, 2016, Vol. 7, No. 2   doi: 10.5376/gab.2016.07.0002
Received: 14 Jun., 2016    Accepted: 06 Sep., 2016    Published: 25 Oct., 2016

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Turaçlar N., Koç M., Yurdakul H., Tezcan Y., and Vural H., 2016, Influence of Radiotherapy on Frequency of Sister Chromatid Exchange, Micronuclei and Binuclear Cells in Breast Cancer Patients, Genomics and Applied Biology, 7(2): 1-7 (doi: 10.5376/gab.2016.07.0002)

The aim of this study was to evaluate any cytogenetic change in sister chromatid exchange (SCE), micronuclei (MN) and binuclear cell (BNC) of peripheral blood lymphocytes in breast cancer patients treated with postoperative radiation therapy (RT). Frequency of the SCE, MN and BNC were examined in 22 breast cancer patients received RT and 10 healthy individuals. All parameters were measured before (RT-a), at the completion of (RT-b) and three months after the completion of (RT-c) RT. A significant difference emerged in SCE (p=0.008) and MN (p=0.004) between RT-a and control groups. There was not any statistically significant difference in the SCE frequencies between RT-b and RT-c measurements. The frequencies of MN were also significantly higher in RT-b (p=0.005) and RT-c (p=0.005) than in control group. MN levels decreased to pre-RT levels three months after completion of treatment. Increasing MN and SCE frequencies following radiotherapy is an expected situation. Decrease in MN frequency at 3-month after the completion of RT suggests that expected repair continues. Persistent SCE at the same period suggests that recovery in SCE has not completed yet and a longer period of time is needed.

MN; SCE; RT; Breast ca