Gao Yuan , Fang Xiaoxiao , Jing Xinghui , Wang Junfeng

Zunyi Medical College in Zhuhai campus, Zhuhai, 519000, China
Author    Correspondence author
Genomics and Applied Biology, 2018, Vol. 9, No. 1   doi: 10.5376/gab.2018.09.0001
Received: 15 Nov., 2017    Accepted: 05 Dec., 2017    Published: 12 Jan., 2018

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Fang X.X., Jing X.H., Wang J.F., and Gao Y., 2018, Research progress of marinobufagenin and salt-sensitive hypertension, Genomics and Applied Biology, 9(1): 1-5 (doi: 10.5376/gab.2018.09.0001)

Salt-sensitive hypertension is a special type of hypertension. Because of its special pathogenesis and clinical features, it has attracted more and more attention in recent years. Marinobufagenin is a kind of endogenous digitals-like substance, which is the unitary ligand of Na⁺/K⁺ ATPase widely distributed in human and animal. Marinobufagenin mediates water sodium retention, increases blood pressure, and interferes myocardial and vascular fibrosis and other pathologic mechanisms by blocking Na⁺/K⁺ ATPase and various signaling pathways, which playes an importent role in the occurrence and development of salt-sensitive hypertension. This article hlights recent advances of the relation between marinobufagenin and salt-sensitive hypertension.

Marinobufagenin; Salt-sensitive hypertension; Na+/K+-ATPase; Endogenous digitals-like substance