CReATiNG works by cloning and reassembling natural DNA segments from yeast, allowing scientists to create synthetic chromosomes that can replace their native counterparts in cells. The innovative technique enables researchers to combine chromosomes between different yeast strains and species, change chromosome structures, and delete multiple genes simultaneously. The method is a major improvement over current technology. With CReATiNG, researchers can genetically reprogram organisms in complex ways previously deemed impossible, even with new tools like CRISPR. The field of synthetic biology has emerged as a way for scientists to take control of living cells, such as yeast and bacteria, to better understand how they work and to enable them to produce useful compounds, such as new medicines. CReATiNG offers an opportunity to use natural pieces of DNA as parts to assemble whole chromosomes

 

The method makes advanced genetic research more accessible by significantly lowering costs and technical barriers so scientists can unlock new solutions to some of the most pressing challenges in science and medicine today. One of the most striking aspects of the study, according to the researchers, is how rearranging chromosome segments in yeast can alter their growth rates, with some modifications resulting in up to a 68% faster or slower growth. This discovery highlights the profound impact that genetic structure can have on biological function and opens up new research pathways to further explore these relationships.