Review and Progress

Structural Analysis of Drugs by Cryo-electron Microscopy Reveals Their Mechanisms of Action  

Jiayao Zhou
Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, China
Author    Correspondence author
Bioscience Methods, 2024, Vol. 15, No. 1   doi: 10.5376/bm.2024.15.0006
Received: 08 Jan., 2024    Accepted: 17 Feb., 2024    Published: 28 Feb., 2024
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Zhou J.Y., 2024, Structural analysis of drugs by cryo-electron microscopy reveals their mechanisms of action, Bioscience Method, 15(1): 50-57 (doi: 10.5376/bm.2024.15.0006)


Cryo-electron microscopy is a crucial tool for studying the mechanisms of drug action, as it provides high-resolution structural analysis of biological macromolecules, revealing the interactions between drugs and these macromolecules. This study delves into the importance of drug action mechanisms and the challenges they pose. It begins by introducing the principles, workflow, and widespread applications of cryo-electron microscopy in biological macromolecule structure analysis, particularly its unique advantages in drug mechanism studies. Through several successful cases, the study illustrates the practical applications of cryo-electron microscopy in drug mechanism analysis, explores its use in drug screening and optimization, and how it can accelerate the discovery and development of new drugs. The paper concludes by summarizing the significant role of cryo-electron microscopy in drug mechanism analysis and looking ahead to its future potential and applications in drug research and development. This research aims to provide new perspectives and methods for studying drug action mechanisms through cryo-electron microscopy, contributing to the advancement of drug discovery and development.

Cryo-electron microscopy; Drug mechanism of action; Biological macromolecule structure; Drug discovery; Interaction mechanism
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