Jun Li , Jing He

Animal Science Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Bioscience Methods, 2024, Vol. 15, No. 4   doi: 10.5376/bm.2024.15.0017
Received: 12 May, 2024    Accepted: 23 Jun., 2024    Published: 15 Jul., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Li J., and He J., 2024, Eliminating porcine pathogens: the role of genetic modifications in enhancing biosafety of transplantable pig organs, Bioscience Methods, 15(4): 162-172 (doi: 10.5376/bm.2024.15.0017)

This study aims to explore genetic and biochemical strategies for eliminating porcine pathogens, thereby enhancing the biosafety of transplantable pig organs. This exploration includes an assessment of current progress in genetic modifications and their effectiveness in reducing or eliminating pathogen-related risks. Key findings in this study highlight important genetic traits and biochemical pathways that contribute to the elimination of porcine pathogens. These advancements include the application of gene editing technologies, such as CRISPR/Cas9, and the development of transgenic pigs that exhibit resistance to specific pathogens. Furthermore, the study discusses the role of antimicrobial peptides and immune system regulation in enhancing pathogen resistance. The results of this study emphasize the crucial role of genetic modifications in ensuring the biosafety of transplantable pig organs. By effectively eliminating or reducing the presence of porcine pathogens, these strategies are expected to advance the field of xenotransplantation and address the organ shortage crisis. The significance of these findings suggests that the future of pig-to-human organ transplantation will move towards a safer and more effective direction.

Genetic modification; Porcine pathogens; Biosafety; Transplantable organs; Xenotransplantation