Ruijie Zhang , Yongshuai Jiang , Hongchao Lv , Xuehong Zhang , Peng Sun , Yan Zhang , Mingming Zhang , Jin Li , Zhenwei Shang , Xia Li

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China
Author    Correspondence author
Computational Molecular Biology, 2011, Vol. 1, No. 3   doi: 10.5376/cmb.2011.01.0003
Received: 19 Oct., 2011    Accepted: 09 Nov., 2011    Published: 28 Nov., 2011

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Zhang et al., 2011, CDRH: A Database of Complex Disease-related Haplotypes in Human, Computational Molecular Biology, Vol.1, No.3 12-19 (doi: 10.5376/cmb.2011.01.0003)

Many common variations in DNA sequences and their specific combinations (haplotypes) may be the underlying causes of differences in individual susceptibility to complex diseases. Great progress has been made in accumulating abundant resources relating to complex disease-related haplotypes. However, these resources are scattered among different literatures, resulting in reduced utilization of the information. Therefore, we developed a database of complex disease-related haplotype in human (CDRH). To date, a total of 1,125 haplotypes involved in 114 complex diseases, such as breast cancer, type 2 diabetes, and rheumatoid arthritis, have been manually extracted from 274 papers. After careful review of these literatures, we obtained detailed information on haplotypes and diseases. Furthermore, we integrated gene- and SNP- (and/or microsatellite-) related information from external databases to facilitate further analysis. Via a user-friendly interface, users can query the CDRH by disease name, gene name, chromosome number, or SNP ID (rs#). We hope that CDRH will enrich our knowledge of haplotypes and promote research into the relationship between haplotypes and heritable risk for complex diseases. The CDRH database is freely available at http://bioinfo.hrbmu.edu.cn/cdrh.

Molecular biology; Genomics; CDRH