Review Article

The Role of the Creatine Phosphate System in Energy Storage and Release: From Molecular Mechanisms to Physiological Functions  

Wenying Hong , Wenzhong Huang
Biomass Research Center, Hainan Institute of Tropical Agricultural Resouces, Sanya, 572025, Hainan, China
Author    Correspondence author
Journal of Energy Bioscience, 2025, Vol. 16, No. 1   
Received: 03 Jan., 2025    Accepted: 12 Feb., 2025    Published: 21 Feb., 2025
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract

The creatine phosphate system helps process energy in cells, especially in tissues that require a lot of energy and change quickly, such as muscles and brains. This study mainly talks about how the creatine phosphate system works, its basic principles, the pathways involved, and its role in the body. We focused on creatine kinase, which helps cells regenerate ATP, and also plays a role in "storing" energy, and is even responsible for transmitting energy to where it is needed. This process is very critical during muscle contraction and brain function, especially in those organs that use a lot of energy, it can help cells maintain a stable energy state. The article also mentioned that supplementing creatine phosphate may help some diseases, such as muscle diseases and neurodegenerative diseases. Now, because of the increasing advancement of technologies such as molecular imaging and bioinformatics, people have a deeper understanding of how creatine is metabolized and how it cooperates with other cellular processes. In the future, researchers may try to develop some new therapies related to creatine. We will continue to explore how it is regulated at the molecular level and see how it is related to other metabolic pathways. These studies are expected to bring new ideas and treatments for treating some energy-related diseases.

Keywords
Creatine phosphate system; Energy metabolism; Creatine kinase; ATP buffering; Therapeutic potential; Metabolic integration
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