Xicheng Yang , Jie Gao

China Biotech Pharma Holdings Limited, Beijing, 100020, China
Author    Correspondence author
Computational Molecular Biology, 2024, Vol. 14, No. 3   doi: 10.5376/cmb.2024.14.0015
Received: 21 Apr., 2024    Accepted: 09 Jun., 2024    Published: 27 Jun., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Yang X.C., and Gao J., 2024, Advances in biomechanics: exploring biophysical models in cellular mechanics, Computational Molecular Biology, 14(3): 125-133 (doi: 10.5376/cmb.2024.14.0015)

Biomechanics and cellular mechanics provide crucial insights into how cells respond to their environment, influencing various biological processes and pathology. This study explores the evolution of biophysical models for understanding cell behavior and reviews their development from early mechanical methods to modern hybrid models. The key model types-continuous mechanics, discrete element models, and hybrid methods-were emphasized, as well as their applications in studying cell deformation, migration, and cell-cell or cell-matrix interactions. Further investigation was conducted on the experimental methods and computational techniques used to validate these models, emphasizing the integration of experimental and simulation methods. Despite progress, there are still challenges in expanding models to capture the complexity of cellular processes. The future directions include multi-scale modeling, artificial intelligence, and potential applications in personalized healthcare. Biophysical models will continue to play a key role in advancing biomechanical research and deepening understanding of cellular mechanics in health and disease.

Cellular mechanics; Biophysical models; Continuum mechanics; Cell deformation; Computational simulations