Yinghua Chen , Hui Xiang , Zhongqi Wu

Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Computational Molecular Biology, 2025, Vol. 15, No. 6   
Received: 07 Sep., 2025    Accepted: 20 Oct., 2025    Published: 10 Nov., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Extremophiles have evolved unique physiological mechanisms and genomic characteristics in extreme environments such as high salt, high temperature, high pressure, and strong acid. Studying their genetic basis is of great significance for revealing the adaptive evolution mechanisms of microorganisms and discovering functional genes with biotechnological value. This study aims to assemble and annotate the genome of a newly isolated polar bacterium and analyze its metabolic potential, environmental adaptation mechanism and evolutionary characteristics through comparative genomics. Functional annotations reveal that the genome of this strain is rich in key functional genes related to salt tolerance, heat resistance, heavy metal resistance, etc. In the comparative analysis with other known polar bacteria, conserved core gene clusters, species-specific gene islands, and the expansion of gene families in response to environmental stress were discovered. Case studies show that it has application potential in the development of industrial enzymes and the construction of synthetic biology platforms. This study provides a new genome-level perspective for understanding the adaptation mechanisms of polar microorganisms and lays a foundation for their functional exploration and application development.

Polar microorganisms; Genome assembly; Comparative genomics; Salt resistance; Phylogeny