Jingya Li , Mengyue Chen

Animal Science Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Bioscience Methods, 2025, Vol. 16, No. 6   doi: 10.5376/bm.2025.16.0029
Received: 01 Oct., 2025    Accepted: 13 Nov., 2025    Published: 02 Dec., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Li J.Y., and Chen M.Y., 2025, Observation of genetic markers for resistance to gastrointestinal parasites in goats, Bioscience Methods, 16(6): 299-307 (doi: 10.5376/bm.2025.16.0029)

 

In many small-scale farmers and grazing systems, the biggest problem that goats face is not the shortage of feed, but the health risks and production losses caused by gastrointestinal parasites. Although such problems have long existed, they are now even more troublesome - the old method of relying on deworming drugs to solve them is becoming less and less effective at present. On the one hand, drug resistance is intensifying; on the other hand, the pressure of environmental protection and sustainability also forces people to rethink their strategies. This study systematically explored the genetic basis of goat resistance to parasites, with a focus on analyzing key genetic markers related to immune response, intestinal barrier function, and inflammatory regulation. It also reviewed the application progress of different types of markers such as microsatellites (SSR), single nucleotide polymorphisms (SNPS), and candidate genes in resistance research. And strategies such as QTL mapping, genome-wide association analysis (GWAS), and gene expression analysis were evaluated. Through case comparisons of breeds such as Boer goats, native goats, Indian Jamunapari and African Red Maasai, this study reveals the diversity of resistance genes among breeds and their specific characteristics. This study emphasizes the significance of strengthening multi-group joint analysis and data sharing, providing a theoretical basis for building an ecological and sustainable goat anti-parasitic breeding system.

Goat; Gastrointestinal parasites; Genetic resistance; Molecular marker; Mark-assisted selection